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By John Stirling Meyer and J.P. Schadé (Eds.)

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Our studies (Hadjiev and Marinova, 1970) on the effects of intravenous administration of 50 mg of cocarboxylase on cerebral hemodynamics and metabolism in patients with vascular lesions of the brain, carried out by using the venous radioisotope dilution technique, showed a significant decrease in the lactacidosis of the jugular blood and irregular changes in the cerebral blood flow. In some observations cerebral vascular resistance increased and the volume velocity of the blood flow diminished.

The tests associated with change of position, especially the Trendelenburg position, are of value for the assessment of the cerebral vascular reactivity and of the state of the cerebral venous vessels. , 1961). In normal subjects, this test produced a slight decrease in the amplitude ofthe occipitomastoid rheoencephalogram contralaterally to the turning, and an increase ipsilaterally. Milder changes occurred in the occipito-mastoid tracings during occipital flexion of the head (Yarullin, 1967).

The method thus enables one to detect disorders in the arterial and venous vessels of the brain. A number of cardiovascular and humoral factors affect the cephalic impedance and hence, the rheoencephalogram. The lumen and tone of the cerebral vessels are influenced by the arterial and venous pressure, the pulse rate and some metabolic factors. Additional information on these parameters is therefore required for the correct interpretation of the rheoencephalogram. If as a result of miscellaneous influences the arterial pressure remains unchanged or declines, the amplitude of the rheoencephalogramincreases and the relative portion of the anacrote diminishes - all these are signs of reduced cerebral vascular tone.

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