By Hans H. Kreipe MD, Reinhard von Wasielewski MD (auth.), Prof. Dr. med. Manfred Dietel (eds.)
From its creation, oncological chemotherapy has been laden by means of its bad selectivity simply because so much antiproliferative medicines are poisonous not just to tumor cells but additionally to special populations of the body’s non-neoplastic cells. the consequent issues of unwanted effects are compounded by way of problems in predicting the specified efficiency of chemotherapy in person patients.
This unsatisfactory scenario has pushed in depth learn and improvement in the direction of extra particular and not more poisonous anticancer medications over the past few many years. a number of result of those efforts have reached the hospital and an excellent better quantity at the moment are in preclinical testing.
Common to a lot of these distinct cures is their interplay with outlined molecules current on melanoma cells, which provides a number of levels of elevated selectivity to their poisonous results. in this case, detecting the objective molecule on tumors ahead of remedy holds nice diagnostic power for predicting the efficacy of the drug and personalizing treatment.
This booklet goals to provide translational scientists and clinicians with an built-in serious view at the theories, mechanisms, difficulties and pitfalls of the detailed remedy approach.