By B. Terracini (auth.), P. A. Voûte, Ann Barrett, Jean Lemerle (eds.)
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Congestive heart failure usually appears within 1 year of anthracycline therapy but can occur up to 10 years after treatment . Moreover, in the same time period echocardiographically detectable abnormalities of the left ventricular afterload and contractility may be observed . Factors which may increase the risk of anthracyclineinduced congestive cardiomyopathy include: (a) previous mediastinal irradiation , (b) host factors (age under 1 year, liver dysfunction), and (c) schedule of administration (bolus injection) [99, 100].