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By B. Terracini (auth.), P. A. Voûte, Ann Barrett, Jean Lemerle (eds.)

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Brouwers P, Fedio P, Riccardi R (1984) Attentional deficits in long-term survivors of childhood acute lymphoblastic leukemia (ALL). J Clin Neuropathol 6: 325-336 92. Peylan-Ramu N, Poplack DG, Simon RM (1977) Computer-assisted tomography in 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. methotrexate encephalopathy. J Comput Assist Tomogr 1: 216-221 Olson RD, Mushlin PS (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypothesis. FASEB J 4: 3076-3086 von Hoff DD, Maxwell WL, Basa et al.

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 103: 620-625 51. Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sherr D, Solomon E, Spurr NK (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328: 614-616 52. Viskochil D, Buchberg AM, Xu G, Cawthon RA, Stevens J, Wolff RK, Culver M, Carey JC, Copeland NG, Jenkins NA, White R, O'Connell P (1990) Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

Congestive heart failure usually appears within 1 year of anthracycline therapy but can occur up to 10 years after treatment [97]. Moreover, in the same time period echocardiographically detectable abnormalities of the left ventricular afterload and contractility may be observed [98]. Factors which may increase the risk of anthracyclineinduced congestive cardiomyopathy include: (a) previous mediastinal irradiation , (b) host factors (age under 1 year, liver dysfunction), and (c) schedule of administration (bolus injection) [99, 100].

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