Download Cancer Biomarkers: Analytical Techniques for Discovery by Mahmoud H. Hamdan (Author), Dominic M. Desiderio (Series PDF

By Mahmoud H. Hamdan (Author), Dominic M. Desiderio (Series Editor), Nico M. Nibbering (Series Editor)

Content material: review -- Proteomic structures for biomarkers discovery -- a few present melanoma biomarkers -- power melanoma biomarkers -- Protein networks and protein phosphorylation in melanoma -- moral matters and projects suitable to melanoma biomarkers

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Karpf, A. , Jones, D. A. (2002) Oncogene 21, 5496. Leffers, H. , Madsen, H. , et al. (1993) J. Mol. Biol. 231, 982. Link, A. , Scvhieltz, D. , et al. (1999) Nat. Biotechnol. 17, 676. Liotta, L. , et al. (2003) Cancer Cell 3, 317. Lyer, V. R. (2001) Nature 409, 533. MacCoss, M. , McDonald, W. , et al. (2002) PNAS. USA 99, 7900. MacBeath, G. (2002). Nat. Genet. Supl. 32, 526. , Mayer, B. , Nollau, P. (2003) Mol. Cell. Proteomics 2, 215. , Misek, D. , et al. (2001) Proteomics 1, 1279. Malik, S. , Ghosh, P.

Today, the expression of thousands of genes can be simultaneously assessed under different conditions, including disease state and treatment. Powerful technologies including PCR, SAGE, single nucleotide polymorphism analyses, and microarrays can target almost any DNA, RNA, or protein sequence. , 2002). A drawback NEW APPROACH TO BIOMARKERS DISCOVERY 7 of DNA microarrays is their unsuitability for protein analysis. , 1999). , 2004; Rammensee, 2004). Although it is still too early to compare the success of protein microarrays with that already achieved by their DNA counterparts, there is no doubt that the first type of microarrays has made substantial progress in terms of construction and applications, including the area of biomarkers discovery.

2005) Mol. Cell. Proteomics 4, 144. 2 PROTEOMIC PLATFORMS FOR BIOMARKERS DISCOVERY Currently we have a number of cancer markers, which are routinely used for screening, diagnosis, prognosis, and for monitoring response to therapeutic treatments. Most of these markers have been discovered using immunological and monoclonal antibody assays. With the completion of the human genome project and the unprecedented progress in proteomic and bioinformatics, the balance has shifted toward the use of high throughput proteomic and genomic approaches in the search for new cancer biomarkers.

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