By Erwin Neher, Wolf Almers (auth.), Illani Atwater, Eduardo Rojas, Bernat Soria (eds.)
Pancreatic a-cell biophysics has gone through a veritable informa tion explosion some time past years. unmarried channel and macroscopic currents became simply obtainable following the advent of the patch clamp method. as well as this new process, extra improvement of strategies for optical measurements, ion-sensitive microelectrodes, permeabilized cells and mathematical modelling have lately extra to the now classical ideas of membrane strength recording and tracer flux size. The foreign Workshop on Biophysics of the Pancreatic a-Cell held in Alicante (Spain) on Sep tember 30 - October 1, 1985, has now given us the chance to proportion studies with those new innovations utilized to the a-cell. additional extra this was once the 1st party for many of the teams doing patch clamp experiences of the a-cell to settle on applicable nomenclature and to discuss the several features of the a-cell ionic channels. To make this data to be had to the bigger clinical group a list of the assembly has been assembled during this publication. it's a number of study papers by means of prime scientists on the meet ing engaged on biophysical, biochemical and physiological points. of secretion. We grouped their contributions in seven sections, includ ing new experimental techniques, K-channels, Ca-channels, function of ionic channels, intracellular ionized calcium, neural rules and mechanisms of insulin unlock. each one part supplies an account of the nation of the matter on the time of the assembly, and the themes are analyzed from the various views of a number of the contributors.
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Extra info for Biophysics of the Pancreatic β-Cell
1 s). The predicted response was calculated adjusting the apparent diffusion coefficient for K+ representing the diffusion coefficient in the intercellular spaces of the islet. 9xl0- 5 cm 2/s. The apparent An alternative method to estimate the apparent diffusion coefficient follows from its definition,10 where b r is the radial distance from the tip of the electrode to the surface and b t is the difference in time to achieve 63% of the response with the tip inside the islet minus the time taken when the tip is placed at the surface.
6. M. J. Cormier, J. E. Wampler, and K. Hori, Bioluminescence: 7. W. W. Douglas, Stimulus-secretion coupling: the concept and chemical aspects, Fortschr. Cern. Org. Naturst. 30:1 (1973). clues from chromaffin and other cells, Br. J. Pharmacol. 34:451 8. w. (1968). W. Douglas and R. P. Rubin, The role of calcium in the secretory response of the adrenal medulla to acetylcholine. J. Physiol. 159:40 (1961). 9. L. A. Dunn and R. W. Holz, Catecholamine secretion from digitonin-treated adrenal medullary chromaffin cells, J.
M•• ca Analysis of burst kinetics. Frequency histograms of open times (A) and closed times (B). The line is drawn to a single exponential with a time. 48 msec (B, closed time). Frequency histograms were constructed from samples of approximately 2 min duration. potential (between +80 and -60 mV). The variability in the open probability probably reflects differences in the metabolic states of the S-cells (see later). It is clear from Fig. lA that the channel kinetics are complex since the channel shows bursts of activity interrupted by long closed periods.