Download Biomaterials in Hand Surgery by P. Tranquilli Leali, A. Merolli (auth.), Antonio Merolli, PDF

By P. Tranquilli Leali, A. Merolli (auth.), Antonio Merolli, Thomas J. Joyce (eds.)

This concise yet finished ebook is the 1st ebook dedicated to the purposes of biomaterials in hand surgical procedure. It provides uncomplicated wisdom within the box of biomaterials, tissue engineering, regenerative medication, implant layout, and hand joint prostheses, and explores extensive the main subject of metacarpophalangeal joint prostheses in rheumatoid sufferers. in addition, the quantity studies the study tendencies for flexor tendon fix and provides new tough principles for regeneration of peripheral nerves through synthetic nerve courses. the most function of this paintings is to supply info in one devoted ebook that may hence symbolize a short and up to date reference for orthopedic surgeons, hand and plastic surgeons, rheumatologists, and fabrics scientists, in addition to mechanical engineers and citizens in those fields.

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4), so a coarser mesh will also imply a poorer domain approximation. The choice of the mesh is one of the key steps of the whole procedure. Although the results should be mesh independent, it usually isn’t so: a bad mesh can in fact spoil an otherwise well-devised FEM analysis. While there can be advantages in choosing the elements as having more or less the same dimensions, the best trade-off is to use mesh refinement, so that more elements (and nodes) can be used only where they are 3 The Finite Element Method for the Design of Biomedical Devices 39 really needed.

In this section, an overview of some of the most important polymeric and ceramic biomaterials is presented, together with some alternative synthetic peptides that are able to mimic the bioligands present in biopolymers. These synthetic bioligands can be used as functionalization molecules for biomaterial surfaces. Furthermore, the important role of growth factors and other bioactive molecules of natural and synthetic origin in the tissue engineering construct will also be discussed. 1 Collagen Collagen is the main component of the ECM of most soft and hard connective tissues [29].

Santin sequence -GFPGER- of the collagen fibril. Furthermore, it has been suggested that type I collagen may also contribute to cell functions by molecular mechanotransduction [31]. Recent evidence shows that these stimuli regulate the cytoskeleton and, as a consequence, the expression of particular genes within the cell nucleus. The most well-known amino acid sequence present in type I collagen, as well as in other ECM proteins such as fibronectin, is the -RGDsequence. This triplet ensures relatively strong cell adhesion to the ECM as a consequence of its recognition by the plasmalemma integrins.

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