By Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect
A concise one-stop-practical reference for many of the physicians facing fungal infections, Antifungal remedy appeals to infectious illness physicians, transplant surgeons, dermatologists, and intensivists, in addition to simple scientists and pharmaceutical corporation researchers drawn to the country of antifungal remedy. This ebook offers a entire, up to date assessment of the pertinent matters referring to antifungal therapy. Divided into 4 interrelated sections for a cohesive dialogue covers:
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Iron overload and deferoxamine therapy have been associated with a higher risk of zygomycosis (248,253–257). Iron is an important virulence factor for Zygomycetes, and when deferoxamine binds to iron in the host, it serves as a siderophore for this mold. In a large series study, 65% of infections occurred in males. Underlying conditions included diabetes in 36%, no underlying condition in 19%, and malignancy in 17% (of which 95% were hematologic). The site of infection varied based on the population, but overall, the most frequent locations were rhinocerebral 48% (particularly in diabetics and intravenous drug users), lung 24% (neutropenic patients, SOT patients), skin 19% (penetrating wounds), gastrointestinal 7%, and disseminated infection 3% (burns, prematurity, diabetes) (248).
Brasiliensis remains undeﬁned though the conditions of endemic regions include mild temperatures, many forests, high humidity with plenty of water, rainy summers, and short winters. The areas are also notable for tobacco and coffee farming (306). Naturally acquired infection occurs in armadillos; in humans, it is presumed that the portal of entry may be either via inhalation or traumatic inoculation, with most patients involved in farming activities. The organism undergoes conversion to the yeast form in the lung parenchyma from where it can disseminate.
B. dermatitidis grows on decaying organic material. In North America, the 22 COSTA AND ALEXANDER fungus is found in the south central and southeastern states, states bordering the Mississippi and Ohio River basins, the Canadian provinces and Midwest states that border the Great Lakes, and areas of Canada and New York along the St. Lawrence River, although cases west of the Mississippi River Valley have also been reported (267,268). Africa is also considered an endemic region for blastomycosis (6).