By S M Yentis; Nicholas Hirsch; James K Ip; G B Smith
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Additional resources for Anaesthesia and intensive care A-Z : an encyclopaedia of principles and practice
Anaesthetic agent’. Anaesthesia and Intensive Care. Official journal of the Australian Society of Anaesthetists (formed in 1935) since its launch in 1972. Also the official journal of the Australian and New Zealand Intensive Care Society and the New Zealand Society of Anaesthetists. Anaesthesia, balanced, see Balanced anaesthesia Anaesthesia crisis resource management, see Crisis resource management Anaesthesia, depth of. Anaesthesia is generally accepted as being a continuum in which increasing depth of anaesthesia results in loss of consciousness, recall, and somatic and autonomic reflexes.
8 GABAA receptor showing GABA and drug binding sites 27 28 Aminoglycosides of endogenous GABA at low concentrations, while directly activating the receptor at higher concentrations. ◗ GABAB: G protein-coupled receptor, linked to K+ and Ca2+ channels via phospholipase C and adenylate cyclase. Activation results in increased K+ and decreased Ca2+ conductance, reducing neuronal excitability. Mediate long-acting, tonic inhibitory signalling. Site of action for baclofen. Franks NP (2008). Nat Rev Neurosci; 9: 370–86 hepatic failure, and during therapy with cimetidine, erythromycin and ciprofloxacin.
May precipitate admission to hospital as a consequence of acute alcohol poisoning or intoxication, or impaired organ function resulting from chronic abuse; may also complicate the management of incidental disease or surgery. ● Effects of chronic alcohol intake: ◗ cerebral/cerebellar degeneration, peripheral neuropathy, psychiatric disturbances (Wernicke’s encephalopathy, Korsakoff’s psychosis). ◗ withdrawal may lead to tremor, anxiety, hallucinations, convulsions, delirium tremens. ◗ gastritis, peptic ulcer disease, oesophageal varices; may lead to gastrointestinal haemorrhage.