By Herbert E. Spiegel (Eds.)
For greater than thirty years, this serial has broadened the technical scope and elevated the clinical base of medical chemistry. those volumes make clear the components of molecular biology and informatics and the tracking of physiological parameters in serious occasions as they pertain to medical chemistry. every one quantity of Advances in medical Chemistry comprises an index, and every bankruptcy contains references.
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Extra info for Advances in Clinical Chemistry, Vol. 36
Cystatin C (Formerly Post-γ -globulin, γ -Trace Protein). Cystatin C is a new parameter in a spinal fluid and serum (plasma), originating from glial elements and belonging to so-called trace proteins. Its increase in CSF is considered to be a marker of tissue destruction. Assessment of cystatin C in serum (plasma) is a marker of renal glomerular filtration. 5. Adrenomedullin (AM). Adrenomedullin is a polypeptide produced by vascular smooth muscle, nerve, heart, and other organs. An increased serum concentration has been reported in patients with essential hypertension, heart failure, and renal failure.
INTRODUCTION Borreliosis is a disease that frequently and typically affects both the central and peripheral nervous systems (Table 13; for a historical overview, see Table 14). Owing to the frequent occurrence in our area, it is possible to observe highly variable clinical manifestations as well as different types of pathological appearances in cerebrospinal fluid. Current methods used in neuroborreliosis diagnosis include the evaluation of specific antibodies: IgM, IgG detected by ELISA, Western blot, and PCR.
Levels of CSF AT III were substantially higher in pleocytic CSF cytological syndromes than in oligocytic syndromes. Antithrombin III in cerebrospinal fluid can be easily denoted as an inflammatory marker. Correlations with levels of immunoglobulins, their intrathecal oligoclonal synthesis, complement components, and acute-phase reactants confirm such concepts. Correlations with apolipoproteins and with the presence of lipophagic macrophages in cytological preparations confirm the elevation of CSF AT III levels when a destructive lesion of the CNS is present.