By Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman
Because the 3rd major explanation for loss of life within the usa, stroke debts for one in each fifteen deaths and is the foremost explanation for incapacity within the state. Compiled by means of a well known editorial group, this reference bridges the distance among easy technology and sufferer care protocols, and collects forty three expertly written chapters that diversity from laboratory-based examine on animal versions to the development, mechanisms, remedy, and diagnosis of illnesses corresponding to subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and worldwide cerebral ischemia.
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Additional info for Acute Stroke: Bench to Bedside (Neurological Disease and Therapy)
Cat models of vasospasm, however, have decreased in popularity in recent years due to the limited availability of biologic tools for protein analysis, scarce genetic information, and poor characterization of the onset and progression of vasospasm. 6 PRADILLA ET AL. RAT MODELS Although rats have been used extensively to reproduce vasospasm, a number of issues have limited the applicability of the obtained findings to the human disease, among them the lack of myointimal cells in intracranial vessels that might play a role in the intimal hyperplasia observed after vascular injury (106), high mortality rates, and early resolution of vasospasm.
Temes, MD, Fellow Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA Quoc-Anh Thai, MD, Assistant Chief of Service, Instructor Department of Neurosurgery, Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA Contributors xxiii Richard J. Traystman, PhD, FCCM, Professor a, Associate Vice President b, and Associate Dean c Department of Anesthesiology & Perioperative Medicine, b Research Planning and Development, c Research School of Medicine, Oregon Health & Science University, Portland, Oregon, USA a Stanley Tuhrim, MD, Director a, Professor b a Division of Cerebrovascular Diseases, b Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA Kenneth R.
J Neurosurg 2003; 99:376–382. 33. Pradilla G, Thai QA, Legnani FG, et al. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. Neurosurgery 2005; 57 (1 suppl):184–190. 34. Afshar JK, Pluta RM, Boock RJ, Thompson BG, Oldfield EH. Effect of intracarotid nitric oxide on primate cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg 1995; 83:118–122. 35. Findlay JM, Weir BK, Steinke, D, Tanabe T, Gordon P, Grace M.