By Anthony E. Redington, Alyn H. Morice
A finished assessment of the clinical and scientific facets of acute and protracted cough, this reference makes a speciality of fresh advancements in our figuring out of the molecular biology of putative cough receptors, the neural mechanisms fascinated about the afferent and efferent limbs, the important processing of the cough reflex, and peptides and different components which could mediate or modulate the cough reflex. With chapters wriitenby said specialists within the box, this guide covers present and power healing brokers, quite a few methodologies to degree cough reflex sensitivity, and scientific techniques for the evaluate of power cough in adults and youngsters.
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Additional resources for Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205)
Kress M, Zeilhofer HU. Capsaicin, protons and heat: new excitement about nociceptors. Trends Pharmacol Sci 1999; 20:112–118. 23. Welch JM, Simon SA, Reinhart PH. The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc Natl Acad Sci USA 2000; 97: 13889–13894. Molecular Biology of TRPV1 and Related Receptors 17 24. Premkumar LS, Agarwal S, Steffen D. Single-channel properties of native and cloned rat vanilloid receptors.
The Ca2þ/calmodulin-dependent kinase II, the only calmodulin-dependent enzyme known to be colocalized with TRPV1 in dorsal root ganglion neurons, is not likely to be involved in these phenomena (72,73). An additional region proposed to participate in Ca2þ-dependent desensitization of TRPV1 is residue Y671 in the TM6 domain (74). Y671 does not seem to be affected by phosphorylation-related processes. However, mutations (Y671K or Y671R) may alter the gating properties of TRPV1 according to biophysical assessments including relative ratio of cation permeability, current–voltage relationship, and altered capsaicin sensitivity.
Endovanilloid signaling in pain. Curr Opin Neurobiol 2002; 12:372–379. Molecular Biology of TRPV1 and Related Receptors 21 84. Hilgemann DW, Feng S, Nasuhoglu C. The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE 2001; 2001:RE19. 85. Minke B, Cook B. TRP channel proteins and signal transduction. Physiol Rev 2002; 82:429–472. 86. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor.